I think this is going to be a very tough game. The Patriots' defense is being reshaped - new pass rusher, young linebackers, new CBs. Watson is a stud who shredded the Pats last year. As a brand new player in the league, he threw for 301 yards and 2 touchdowns, and also ran for 41 yards. Very very dangerous.
Offensively, they're thin at WR, but fortunately, Gronk is ready to go. The last three times Brady has faced Hou (including playoffs):
12-13-15 (road): 22-30, 226 yds, 2 td, 0 int, W, 27-6
1-14-17 (home): 18-38, 287 yds, 2 td, 2 int, W, 34-16
9-24-17 (home): 25-35, 378 yds, 5 td, 0 int, W, 36-30
Averages: 22-34, 297 yds, 3 td, 1 int, 32 points scored
I feel confident that Brady will play well, but it's still going to be a difficult game. It's a good thing it's home, but that will only make it worse if they lose.