Yes, of course.
1-3 IOL's is a given, including someone who can at least compete to be the starting LG.
With the new rules allowing an extra active OL, we will almost certainly carry 9 OL's: 4 OT's and 5 IOL's
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FIVE INTERIOR LINEMEN
Andrews and Onwenu
AND THEN? Ferentz, Desjarlais, Sherman and Hambright
Ideally, only one of these makes the 53. One of the backups will need to be the backup center, ready to start a few games if necessary. I would not be surprised to see Ferentz make the 53, since the coaches seem content to have him as the 9 OL, active on Game Day, backing up both OG and C.