The refs need to call fewer penalties. However, the players also need to be better schooled in how not to commit penalties. With the league making significant changes to the rules every offseason, it would seem part of these penalties is the result of players not understanding what is and is not a penalty.
In my opinion, the league would be wise to reprioritize what gets called more than just increase the number of penalties. As poor as it would be for defensive chess matches, the league could loosen up on offensive line holding since it protects quarterbacks and increases offensive output while emphasizing further penalties called for the shots to the head and knees.
Across the season, officiating teams should be kept to a set average of penalties to keep the game flowing while also protecting players. This is a product for entertainment, not a quibbling match.