My two cents: the Patriots' A game is better than anyone else in the league's A game. Their B game is worse than the A games of Indy, Pit, Bal, GB, NYJ, etc. So the other teams have a chance if they bring their A game and the Patriots bring their B game (or worse). But if the Patriots play their A game, there isn't another team in the league that can match that.
So while there are many individual things that we could worry about (the running game, turnovers, pass protection, etc.), the fact is that if NE plays like they are capable of, they will win, pure and simple.
So we just need to hope like crazy that NE brings its A game.