No. I don't think they will rest starters unless the game gets out of hand either way. The young players need all the playing time they can get (the young starters that is).
As for the third or fourth seed, too much has yet to be determined and that will still be the case heading into the Houston game. Frankly speaking, at Indianapolis and at SD will both be daunting tasks. Regarding the colts, I wouldn't be so confident. Just think - what if the Colts actually start off strong and don't get down early, which they will make a point of doing for sure?