No. Even if they had a dynamite off season they'd still have big holes in the roster. There's no way to fix that in one year.
The first step to making the playoffs is winning the division. The Bills have won between 11 and 13 games a season for the last 5 years. Pats aren't making that jump next year. So you are talking wildcard. Sadly the AFC is loaded with teams competing for wildcard spots. The Steelers, Broncos, Chargers, Bengals all have QB's and better teams. And that's not accounting for teams that also could take a jump that are in the mix like the Dolphins and Colts that are basically above average.
You needed at least 10 wins to make the playoffs this year. There's 10 teams in the AFC that either hit that mark or are within 2 games of it.
Won't happen.
Where I disagree with many of the no votes is on the number of holes they have to fill. I don’t disagree that they have numerous holes to fill, but I believe that they can fill one hole, and in some cases two, and by doing so improve the entire unit. However they have to nail the choices they do make to fix the problem. But if they nail those 1-2 players they change the entire dynamic, and improve all of their options. Example: if they go into free agency and sign Alaric Jackson and Trey Smith their OL would be fixed. They would have Jackson, Strange, Andrews, Smith, and Onwenu as starters, and current starters would be depth. If they signed a veteran DT, like BJ Hill or Jarron Reed the interior DL would be shored up, and they could draft Abdul Carter and have a front of White, Barmore Hill, and Carter. If they trade for Deebo and drafted Egbuka those two would start with Douglas, and the rest would be depth. So by filling one or two holes at the units in most need they could upgrade all those units across the board, they just have to hit on this signings or draft picks.
OL -2 free agents
RB 1 draft pick
WR-2 1 trade 1draft pick.
DT- 1 free agent or draft pick
DE-free agent or draft pick
LB 2 1 free agent 1draft pick
CB 1draft pick re-sign Jones
IF they can nail these additions each unit would improve significantly, and this would make them a playoff team, and they have enough $$$ and draft picks to address each of these and more, they just have to get the choices right.
At WR I mistakenly said one trade one free agent. I meant one trade one draft pick. I edited this to reflect that change.