Bills are going to throw short to the RBs Singletary & Cook, screens to McKenzie over and over and over, because in the last 3 games that's what they did and the Patriots are yet to stop it.
The alternative is worse though frankly. If the Pats move up their coverages and go more press man the Bills can both go over the top to great matchups like Diggs or whoever Bryant is on, plus likely lose whoever spies Allen (like they've done with Wilson. MacMillan and Duggar in past games) and have him literally run wild.
That's BIG play heaven versus death by a thousand cuts.
That said...maybe play more safeties, more light LBs (Peppers, Wilson, MacMillan) and let them run?? I dunno none of the options are "better" frankly.