Several years ago, the Pats finished a season as the least-penalized team in the league by a notable margin over the second-least-penalized team. That, of course, incited all sorts of spittle-flecked complaints about "ref bias" in favor of the Pats. What no one bothered to notice was that, nearly the entire difference in penalty counts between the Pats and the league average was accounted for by the Pats lack of "false start" and "offsides" flags - the penalties that are the least open to ref interpretation of the rules.
Anyway, the good news is that the perennial big-hitters on other teams who will likely be most affected by the new rule (and unpredictable interpretation/enforcement), are also frequently among the best defensive players on those teams. Many of those players may not be able to adjust their playing style and still retain their effectiveness.
Advantage: Patriots.