Brady got hurt, Faulk got hurt, Neal got hurt, the TEs all got hurt, and the Patriots lost, after taking a late lead, by the grace of a non-call on holding against Seymour, a slow whistle on an "in the grasp" call, a helmet catch by a guy who's done pretty much nothing else in his career, a catch by Burress against a CB with a torn groin, and a pass from Brady to Moss on the final drive that was about 4 inches from being complete. All that combined to give the Giants the biggest upset win in NFL history.
Manning, meanwhile, threw a pick 6 against the Saints to cost his team the game.