RB, time and time again, if you can run, you will be OK.
Now, as for being a RB in a passing situation with blitz pick-up and all that, then rookie it is time to head to the sidelines and let a vet back in.
That is why what Woodhead did last year is so remarkable, he stepped right in, at week 2, without a camp, and picked up the whole thrid down offense.
I might also throw guard into the mix, as the tackles and centers make all of the line calls, so I doubt he have too think too much when the guy next to you is basically telling you who to block before the play.