The Pats Defense is going to have their hands full with Nick Chubb, Amari Cooper, and Njoku. They'll need Jon Jones on Cooper, Dugger on Njoku and Phillips, Bentley, and Judon to be on their best game to handle Chubb.
The Pats Offensive line took Aiden Hutchinson out of the game. They will have to give a similar effort against Myles Garrett. The Browns have an excellent safety Johnson and a good corner in Denzel Ward. The Pats receivers aren't going to be going against a teams 3rd/4th stringers like they did against the Lions. The RB and TE will have to be wary of the Safety Blitz. Something that Johnson has tallied 2 QB hits already with.