She has legitimate beef with the Titans, as does her husband.
Unfortunately, what she wants to happen doesn't actually correlate to what happens on the field and because she wanted it to happen, doesn't mean Coach Belichick was going to let it happen. I have no problem with her speaking her mind about the situation. She isn't on the coaching staff. She doesn't get a pay check from the Patriots. This isn't coming from her husband, but from her mouth.
So there can't be any backlash on the Patriots, Belichick, Brady et al for her comments.
As for running up the score, I remember reading Education of a Coach and there being a story about how Steve had the score ran up on his Navy team (or maybe the other way around). I think the lesson learned from that story was that your not doing the other team any favors by letting up, let alone your own team. Players get on the field and they need to be striving for perfection on each block, each pattern and every coverage. They need to be hunger to win, so it is one thing to pull your starters and another thing to have your back up running back rush the ball till the time runs out. Hoyer had a great opportunity to learn in a game situation, as did the other guys that came in. And their learning makes the team better as a whole.
Sure it comes at the expense of another NFL team, but if they don't like it, they need to make some changes. It isn't the responsibility of the opponent to let up on players and coaches in the NFL, who make a ton of cash, because they were prepared to play, weren't motivated, had injuries, etc. If anything, the Pats did them a favor for showing them who they really are.
Unfortunately, the Pats might be hindered by an inflated ego, if Bill didn't contain it already, after destroying the Titans.