This weekend's game line hasn't changed because of the group of the injured, Hagler is the only one that has contributed every week.
The impact from these injuries will be felt in the coming weeks when the depth, or lack of depth, will be impacted.
Who cares about the weekend line. That is based on where the money is going gambling after the the line is set on Monday. The reason the line hasn't changed is because the gambling public hasn't changed their betting on the game.
As for the losses, I thought the fact that the Colts are going to face the likes of Matt Schaub (twice), Tom Brady, Joe Flacco, and Kyle Orton instead of the QBs they have faced (Kerry Collins, David Garrard, Chad Pennington, Seneca Wallace, Alex Smith, and Marc Bulger) is going to expose the fact that those losses will hurt the Colts. The Colts have been able to overcome the losses of Sanders, Jackson, and Hayden in some games this year because for the most part (other than Arizona) have faced mediocre passing attacks. Warner has had a very up and down season so far this year, but he still was able to pass for 332 yards vs. the Colts which is the most yards he passed this season.
If the Colts had played anyone so far this season, I might say that the losses aren't that big of a deal. But the Colts have only played one team with a .500 or better record and it is the Jeckyl and Hyde Cardinals who probably would be below .500 if they weren't in a weak NFC West.
Starting tommorow, four out of the Colts' next five games are against teams with 4 or more wins (three of them have 5 or more wins). In, their first seven weeks, they faced one. I think this is when the Colts' season starts and I think the injuries on defense will be exposed. Granted, with Manning playing like he is, they can still beat some or even all of those teams. But if I was a Colts' fan I would would be worried that they could get 2-4 losses in the next five weeks. Houston (5-3), New England (5-2), Baltimore (4-3), Houston again, Tennessee (only easy game they have during the stretch at 1-6), and then Denver (6-1) is a tough stretch. A lot easier than the one they just did in Jacksonville (3-4), Miami (3-4), Arizona (4-3), Seattle without Hasselbeck (2-5), Tennesssee (1-6), St. Louis (1-7), and San Fran (3-4).
And before you Colts fans bring up the Pats' strength of schedule so far, they have played far tougher teams with three of them dragging down the winning percentage. The Pats have played Buffalo (3-5), Jets (4-4), Baltimore (4-3), Atlanta (4-3), Denver (6-1), Tennessee (1-7), and Tampa (0-7). So the Pats have played four teams with .500 or better records compared to the Colts' one. The Pats are 2-1 against teams with winning records vs. the Colts' 1-0.