I don't know if I like this matchup as much as some seem to, but then again I am a worry-wart, and sometimes an eternal pessimist.
I think that SD is surely a SB contender, and apparently Vegas does too, as they are one of the odds-on favorites to win the AFC conference and represent them in the Super Bowl. I certainly do not think that SD is a team that you even think of taking lightly.
That said, I like our chances at home, and feel as though the game will be close no matter what..I think that either side has reason to be confident and also reason to be concerned, after all these are 2 of the AFC's higher ranked teams. SD certainly held this offense in check last yr, and we were lucky to get out of there alive on the missed FG at the end of the game. They had the top ranked offense and defense for a reason. No, they aren't the '85 Bears, but they are certainly a team that is more than capable of coming in to Foxborough and walking out a winner.
It will all depend on whether or not our secondary and pass rush are up to the challenge--just like many instances. Rivers and the bigger targets (VJax/Gates) can hurt us if we give them time, which often seems to be a problem on this defense. The middle of the field targets will be something to surely keep an eye on, as they have posed quite a problem for the team in the past. The SD defense is certainly good enough to pose problems too. It helps that Castillo is out.
Either way, I really don't see how either sides fan base is extremely confident, and I expect a closer game.