Once you lose your elite hybrid TE to retirement I don't see any other way than reinventing some of the offense because the main way you were able to keep opponents guessing what's a run and what is a pass and then exploit whatever they committed to is gone now.
I think we will be looking at a lot more spread looks. Personally I think the couple of TE seam routes that we have been seeing the preseason are a red herring to keep the early opponents off balance and prepare for something that will not be on the menu.
At the same time most of the WRs have the necessary physique to block somewhat competently against nickel (or dime) so you can still kinda achieve some balance between run/pass while staying somewhat unpredictable.
All this talk about WRs blocking. I have a direct quote from belichick and later caserio starting “a wide receivers only job is to get open and catch the ball”