Alright, I'll wave a white flag and say truce regarding "running up the score" in order to avoid a thread hijack.
Back to the original subject: it seems to me that offensive holding tends to be called far more often the longer it takes for a QB to throw the ball. Sorry for having no statistical evidence to back that up, but I don't think there are many that will disagree with that claim.
Now the question is who will be hurt more by this new point of emphasis: offenses that take a long time for a pass play to develop, or quarterbacks that tend to get rid of the ball quickly?
The slow-developing offenses have a tendency to need to hold more often simply because they can't protect the QB forever. On the other hand it might be a situation where refs are already flagging offensive lines when a QB takes a long time to throw; it could be that there are not all that many plays of this type that are not already being flagged.
If that is the case and the refs feel pressure to call more offensive holding penalties, then it is possible that even the offenses that feature quick-release quarterbacks will find themselves flagged more often - just to meet the quota.
However, I still think the play that breaks down and the QB that is forced out of the pocket, that is the play that will end up being flagged more often than any other. And in my opinion that means the offensive line in front of quarterbacks like Roethlisberger, McNabb, Garrard, etc. - those are the ones that will most likely see the biggest increase in offensive holding calls.