It'll be a non-issue.
I've seen the majority of Peyton's pre-season reps this year and it's pretty clear that Kubiac is tailoring his offense to fit Peyton Manning's classic style. 3 WR, 1 TE, 1RB; the vast majority of the time. Same formation; sometimes it's under center sometimes in shotgun, they will flip the strength with the TE or slot. They'll deviate from that standard formation mostly with the 'bunch' formation (3 WRs all clustered together) more than anything. Very basic, classic passing concepts; almost always vertical stems to the routes, so it's pretty tough to read the first few steps of the play.
The running game looks little different than what we've always seen with Peyton, too. I swear practically every run I saw was the stretch play; where the running backing goes slightly off-tackle and can cut-in or cut-out based on how the defense reacts. And this run is constantly used to keep the d-line thinking horizontally at the snap, so it can buy Peyton more time against the pass rush. Thet ran that in Indy non-stop with Edgerin James.
This was never Kubiac's style in Hou, certainly not to this degree. When the season starts; if that offense is going no-huddle, and Peyton is often calling audibles at the line (which I saw last weekend) then it's mostly the same system as we've always seen Peyton run. Maybe some new stuff thrown in, but the bread and butter is what Peyton's been doing his whole career.
BTW - and that was how Elway nabbed Peyton in the first place. He agreed to not put Peyton in a totally different system. As opposed to say, Harbaugh in San Fran, who was west coast offense. So, when Elway hired Kubiac, I'm pretty certain that aspect was made clear; same as it was for John Fox and Mike McCoy when Peyton was first brought on board.