It really depends on the personnel, but it seems to me that the best thing for any team to do would be to mix it up at least a little bit. Hopefully you can disguise your coverages often enough that you confuse the QB and hopefully get a couple of turnovers.
If you never blitz you end up with what happened to Jacksonville in the 2007 playoffs, when Brady completed over 90% of his passes. Or you should be able to run the ball effectively, like the Pats did against the Jets. Blitz all the time and somebody's going to not only be open, but faster than the guy covering him. We saw the same thing for years with teams trying to defend against Peyton Manning too.
Too many armchair HCs/fans of other team seem to think 'all you have to do is hit Brady'; well duh, you can say that about pretty much every NFL quarterback. The trick is finding the personnel and a plan to get to the QB before the receivers get open. That's a whole lot easier said than done.