This is actually a great point.
The Indianapolis defense relies on Sanders playing the Safety Hybrid (or "Rover") position. If he's down in the box, SOMEONE will be open, and as much as I like future New England Patriot Marlin Jackson, even if he plays the game of his life and locks down Moss, Hayden on the other side, couldn't cover me. That would mean Bethea would have to rotate over to help, and while Sanders is chillin' in the box, either Keiaho (if he's healthy) or Hagler will have to cover Welker in the slot. Good luck with that. Should Sanders play deep in the traditional Cover 2 shell, the Colts will be lit up by multiple crossing patterns; neither Brackett nor Morris is nimble enough to get a quality jam on a receiver (without hitting him 10 yds downfield), or catch up to one running away from him; and should Watson (please please please) be healthy, he's going to embarass Morris.
The Patriots don't have this problem. They can play a base 3-4 with the 4 defensive backs in coverage. Why? Adelius Thomas. The Dalls game, or even the Washington game..both these teams LOVE to go to the TEs, but outside a couple of catches on one drive by Witten, he and Cooley were both shut down; and this is because Thomas can run with and cover these guys. Dallas Clark is the best of the bunch (and Indianapolis fans will tell you "OMG HE BEAT CHAMP BAILEY"..Bailey wasn't responsible for the coverage on that play...) I still feel confident that Thomas can keep the coverage locked.
That's why this game is a blowout. I think the key (as it usually is with Belichick against explosive offensive teams) will be Addai, and will be spied and chipped all day, limiting Manning's safety valve. If you've watched this version of the Colts, Manning dumps the ball off a LOT more than usual. I'm not worried about the "amazing" Colts running game. Not running on the Patriots, almost no one ever does.
Simply; Patriots should pretty much own the matchup on offense, simply taking what the defense gives them, and exploiting matchups at the skill positions. Normally, this is where you mention Freeney, but we're talking about a different guy since he signed his contract. 7 sacks over the last 2 seasons, and 3 of those were in one game last year against Cincinatti's rookie LT in for injury. Patriots line should have little trouble. Not like the Colts will be blitzing.
The Colts will score points, but it will be a grind. The Patriots will score points at will. It's really that simple. Patriots 52, Indianapolis 27