Now you're just creating a laughably obvious straw man.
I've never said that you shouldn't draft a QB in the first round. Quite the opposite actually, a QB is the most premium position in the NFL.
A team's success rides on their QB. So if anything that is the opportunity cost that I'm talking about.
A guard is NOT a premium position. Neither is RB. In general those positions should not be selected high in the draft because in terms of impact to a team's success, they pale in comparison to for example drafting an impact Quarterback, Pass Rusher, or franchise left tackle. Would you like any more lessons about 'opportunity cost'? I'll be happy to share.
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Let's put it simply. A draft pick is a limited resource that is given to teams by the NFL to acquire new talent to grow or restock their pool of players whom they use to win football games.
When a team uses a 1st round pick, a premium resource, on player A, they are passing on player B. Therefore there is an opportunity cost LOST when you pick a far worse or far less premium player with a costly 1st round pick.
The further you go down in the draft, the more fungible, ie less valuable the cost of draft picks. Teams are far more open to trading away low round draft picks, because these represent less valuable resources. Therefore it makes more sense to draft less 'premium' positions using lower value picks, so as to maximize the value of your earlier draft picks.
If you take for example a non-premium guard in round 4. If he becomes a flop or a success the chances of making a bad opportunity cost selection is reduced because you used a less valuable resource. If however you expend a premium 1st round pick on a guard using your more valuable resource and he doesn't become an all-pro, you have risked MORE and your return is less based on the fact that you've drafted a non-premium position. Is this clear enough to understand? These are just basic economic principles that anyone can understand.
If you need further enlightenment I would refer you to this excellent article about the art of maximizing roster construction by properly valuing premium positions:
Maximizing Roster Construction by Valuing Positions in the NFL Draft | Over the Cap
overthecap.com
This highly informative chart from that article tells us a lot about what we need to know.