If I came across as rude and snippy I apologize. I guess part of it was that I just didn't see the need for a third or fourth thread on the same subject (Moss and Welker being on the injury report and listed as questionable) for one thing. I'm not sure what was expected from his original question; it's not as if somebody here is going to have inside information on whether or not they'll play - and if by chance somebody did, I certainly wouldn't expect them to make that information public.
As for the second part of the original question, isn't the answer obvious? If any team has to play two backups rather than two pro bowlers at any position, then the expected result would be a dropoff in performance. In other words, yes, two of your best starters not playing will hurt your team's chances to win, especially when playing a good football team. Not exactly rocket science.