It's going to take a combination of things to happen to beat the colts. If the Pats get some decent pressure on Manning to keep their scoring down but Tom can't get them in the endzone, that cancels each other out. As with every football game, who knows what's going to happen - that's part of what makes it fun to watch.
The gist of this post is: the Pats win either way. If they win the game, it's great because they get closer to a playoff berth and spoil Indy's chance to have an undefeated season, and I'll feel good all week. If the Pats lose, it's still good because it seems when 2 teams are evenly matched, the team that wins in the regular season usually loses if they meet in the playoffs (see Pitt breaking the pats win streak, then losing in the playoffs). And, it keeps the pressure on Indy for an undefeated season. That pressure can take a toll the closer you get to the end of the season, and it may compel indy to play Manning and the starters longer to keep the streak alive even when they have nothing else to gain, contributing to more fatigue physically and mentally and getting more dinged up, making them more vulnerable come playoff time. The obvious downside is it's another loss for the Pats, and I'll feel lousy all week.