The Bills D is middle of the NFL pack in nearly every category, so they haven't exactly been terrors of speed and destruction. They've allowed 40 rushing first downs (the Pats have allowed 18, lowest in the AFC), only five teams are worse (including Indy, 43!), so we should be able to run the ball on key downs with some success.
Our defense is playing much, much better than the opening game. Losman will have a tough time going deep to Evans against our defense if they play the way they have lately. The Pats rushing D is 8th best in the league and have allowed only one back over 100yds, Bell for Denver, while shutting down top backs McGahee, Brown, and Johnson. So we should have no problem containing McGahee again - 20 carries for 70yds in the first game.
Losman has been sacked 19 times, 4th most in NFL, for an NFL leading 161yds lost. So expect at least 3-4 sacks minimum and maybe a fumble on one. Th Bills are -4 in turnover margin, only five teams are worse, so we might get one TO somewhere, especially with the confidence Samuel is playing with. Losman has thrown 5 picks, only 6 QB's have more.
Road games don't bother the Pats, they've won many big games away from home, so Buffalo gains little advantage there. Weather looks iffy with rain in the morning then a chance of showers with temps in the 50's.
BB and Co. almost never lose when facing a team for the second time in a season, plus their record coming off byes under BB I think is 5-1.
Add it up and I get NE 23, Buffalo 13.