I'd say picks 3-4-5 are probably the best in the draft. Partly it's because teams are willing to trade up into those spots if you choose to drop down. And if you decide you like the pick, you dont pay the ridiculous salary premiums that the #1 and #2 picks get.
SF is looking good for us, right now. A 2-14 season would be hard to argue with.
If we get, say, the 3rd overall pick in 2008 plus Randy Moss in exchange for our #28 pick in 2007, I'd say that was probably the trade of the century.
We could have had Posluszny or Harris, true. But Moss AND a blue chipper? The last time we picked that high in the draft, we got Richard Seymour.