Makes me think of the term anti-fragile. Things that gain from disorder.
LaFell and getting Dobson to be consistent would certainly open things up all the way. Edleman and Amendola can probably play outside well enough (partly because of Brady's accuracy) to play the intermediate zones as well. i doubt Brady will hold the ball longer to attack the deep part of the field, but have intermediate/outside receivers would certainly be an added tool that Ryan will have to defend.
I doubt we'll see the 6th lineman formation for any power running plays. They might try it early and abandon it if the Bills D is too stout (and they seem to be a top 3 D, but we'll have to see how the season plays out).
Naturally in-game adjustments and perhaps well timed hurry up would help too. I'm not sure how much Ryan rotates his lineman. starting to feel like I'm throwing every possibility out there.