Except how good will Saturday be when he gets back. He is coming back early because of the o-line problems (if he is really even coming back soon because the Colts are notorious for giving impressions players are close to coming back and not playing them for weeks or months). Typically an MCL sprain takes longer to come back and they usually struggle initially.
Also, how long will Ugoh be out. His loss weakens two positions since his replacement was a starter on the other part of the line.
The o-line may improve with Saturday coming back, but I wouldn't expect miracles. Also, I would be worried about the Colts running game if I was a fan. The Colts have been unable to run the ball since last November 4th. That problem has been an issue long before the line problems.
I still don't know if the Colts have the offense to make up for the defense if it is as bad as it was in 2006. The Colts in 2006 had an elite offense that could score quickly consistently. I don't know if that is the case with this offense especially if teams don't have to fear the Colts' running game.
If the Colts have an offense on par to what they had last year, they cannot win many games if they are giving up 150 plus on the ground. Last year's Colt offense was still very good overall, but it clearly wasn't the elite offense that it was in previous years.