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Ok, with the running situation, I will revise my score prediction:
Pats win 27-21
I think Cassel ends up having the better game at QB than Manning. The Pats have a huge advantage with their WRs going up against the Colts' DBs even with Sanders in there. Even more so than the Colts' receiver against the Pats DBs. The Colts could be starting either a #5 CB or moving a safety over to start at CB. That is big.
Pats win 27-21
I think Cassel ends up having the better game at QB than Manning. The Pats have a huge advantage with their WRs going up against the Colts' DBs even with Sanders in there. Even more so than the Colts' receiver against the Pats DBs. The Colts could be starting either a #5 CB or moving a safety over to start at CB. That is big.