If you don't mind me bumping this back up, I'd like to know how Mayo and Guyton will excel in this system if "roaming" in a 2 gap 4-3 is a misconception as Andy points out? (e.g., utilizing Mayo and Guyton's speed).
You now have four DL absorbing blockers, if your point of attack is behind the RT, you will generally need a second DL or TE to have any hope of moving Ty Warren off the mark. You will have a TE/FB/pulling OL looking for the OLB, that puts three blockers at the Point of Attack, which means Mayo is most likely not being blocked.
Let's see if I can set up a basic 4-3 look...
-- TE -- RT -- RG -- C -- LG -- LT
------- LDE - LDT ------ RDT --RDE
--- S --------------- M --------------- W
Using this look above and one-on-one blocking:
-- The TE blocks the Sam.
-- The RT blocks the LDE.
-- The RG blocks the LDT.
-- The C blocks the RDT.
-- The WR on that side blocks the CB or S.
-- The LG pulls and kicks out the DB or Mike.
"If" the Offense can block one-on-one, then you have one defender on that side for the RB to beat, either a DB or the Mike. "But," If Ty Warren is the LDE, you may want to double him with a TE or the pulling LG, that frees up a second defender, most likely Mayo, to make the play on the edge. On the backside, if Guyton at Will reads the pulling LG, he can shoot that gap and try to run the RB down in the backfield. By putting two DL on the right side, the offense needs to account for them. That's what frees up the LBs.