SlowGettingUp
2nd Team Getting Their First Start
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If mere contact were the only reason CTE to occur, wouldn't there be more than just 50 cases over the last 15 years.
Well, first there are obviously a lot more cases than just 50 given the only way to diagnose right now is via post mortem. We simply don't know how many.
Secondly, it seems pretty clear that people have varying degrees of susceptibility to repeated head trauma. Nobody currently knows why - likely there is a genetic component. It is important to understand we are not talking a purely mechanical process here - there is very likely concomitant neuroinflammation in both CTE and in post-concussion syndrome. There is an overlap with both Alzheimer's (tau) and ALS (TDP43) pathology.
Here are a sampling of very recent abstracts that discuss some of these issues:
Postconcussion syndrome: demographics and predictors in 221 patients. - PubMed - NCBI
Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy. - PubMed - NCBI
Prolonged Repetitive Head Trauma Induces a Singular Chronic Traumatic Encephalopathy-Like Pathology in White Matter Despite Transient Behavioral Ab... - PubMed - NCBI