The 2000 schedule has been announced, and Drew Bledsoe and company will open the season at home against the Tampa Bay Buccanneers.
2000 Season Schedule
| DATE | OPPONENT | TIME |
| Sept. 3 | TAMPA BAY | 1:00pm |
| Sept. 11 | at NY Jets (Mon) | 9:00pm |
| Sept. 17 | MINNESOTA | 4:15pm |
| Sept. 24 | at Miami | 1:00pm |
| Oct. 1 | at Denver | 2:05pm |
| Oct. 8 | INDIANAPOLIS | 1:00pm |
| Oct. 15 | NY JETS | 4:05pm |
| Oct. 22 | at Indianapolis | 1:00pm |
| Oct. 29 | OPEN DATE | |
| Nov. 5 | BUFFALO | 1:00pm |
| Nov. 12 | at Cleveland | 1:00pm |
| Nov. 19 | CINCINNATI | 1:00pm |
| Nov. 23 | at Detroit (Thu.) | 12:30pm |
| Dec. 4 | KANSAS CITY(Mon) | 9:00pm |
| Dec. 10 | at Chicago | 12:00pm |
| Dec. 17 | at Buffalo | 1:00pm |
| DEC. 24 | MIAMI | 1:00pm |
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