No, but is unlikely to have self-constructed or result from random mutations. They "may" have? How is that a refutation? It is a counter-argument, maybe. There are other scientific discoveries that have really called into question the idea that the universe and our own little planet happened by chance. We have discussed the cosmological constant before. That is the fly in the "big universe" ointment that is driving the unsupported idea of multiple universes and the idea that there are non-carbon-based life forms out there somewhere.