History does not show a lot of #1 seeds advancing to the SB.
Let's just look at it from 2001-2011, or the "Patriots era".
That's 11 seasons, 22 SB participants, 11 champions.
Seeds making the Super Bowl
#1 - 10 (45.5%)
#2 - 5 (22.7%)
#3 - 2 (9.1%)
#4 - 2 (9.1%)
#5 - 1 (4.5%)
#6 - 2 (9.1%)
Seeds winning the Super Bowl
#1 - 2 (18.2%)
#2 - 4 (36.4%)
#3 - 1 (9.1%)
#4 - 1 (9.1%)
#5 - 1 (9.1%)
#6 - 2 (18.2%)
So the #1 seed has made the Super Bowl 10 out of 22 possible times, by far the best number on the board. So if you want to get to the Super Bowl, the best way to go is as the #1 seed. Once you're there, it's less certain, of course.