Week one is certainly perilous in survivor leagues. Denver losing to Miami one year knocked out about 75% of the players in a huge league I was in. Generally as most people I try and take the worst team who I consider a lock to win there game that week but week one I'm more conservative until I start to figure out which teams are for real and the trends like a team, Seattle, is a lock at home but blows on the road, etc. So week one locks. NE hosting KC. Philly hosting St Louis Are the only true week one locks IMO. A few weeks in if things go as I think this season there's some other games I'd consider taking but these are the only two total mismatches I can find in week one. I'd be interested in the strategy and thoughts of others week to week.