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The answer is I have no idea. You won't ever be allowed to do testing as such because of the medical ethics involved. All you can do is speculate.
I'm not going to dance around the issue. The steroid era of baseball impacted stats more then any other period other then pre-Jackie Robinson era. We can never gauge the impact that racism had on baseball. Steroids, on the other hand, can be calculated to a degree in which someone could logically come up with numbers for fewer home runs.
Stimulants or any other substance played roles in numbers being manipulated, but pale in comparison to steroids (or whatever you want to call them).