Thinking about the game a little more, defensively the DE's or OLB's (depending on personnel) need to stay home and keep Luck in the pocket. You cannot let him roll out because he's deadly while on the run, where a guy like Tebow or Geno Smith is not. Reason for that is his ability to throw an accurate bullet across his body to receivers that will break open once he gets on the move. We should see a lot of two gapping in this game as well, which should mean Siliga gets a lot of snaps. T.Y. Hilton should get frequently beat up at the line of scrimmage with some help over the top. Give him the Torrey Smith treatment from last year's AFCCG. Man handle him within the first five yards, get in his face, and don't let him get a free release. If Indy is smart, and they watch tape of that game, they'll frequently put him in motion or in the slot to avoid the jam. Fleener should still be a big area of concern, IMO. The defense has trouble containing the TE's and he should find some openings in the zone defenses that we'll probably employ.
Offensively, the Colts ranked 26th in run defense this year. If the forecast pans out and it rains, I would expect a heavy diet of the run starting with Blount. They're somewhat undersized up front and Mathis, as good as he is, has a habit of over pursuit. The Pats may employ a gameplan with the running game similar to the one they used against Julius Peppers in the Super Bowl: run right at him. They're also a mediocre pass defense too, in spite of their rank. A lot of what they did against the pass this year was a product of what they did up front. Still, expect them to actively try to take away Edelman and Vereen. That means that Amendola, Thompkins, Collie, etc. will get a lot of one on one opportunities that they will have to win.
In all, this is a good draw for the Pats. Contain Andrew Luck and they should win. Let Andrew Luck improvise and make plays with his feet, and they'll be one and done.